Molecular technique and Genomics have made great impact in crop improvement research. Whole genome sequencing of priority crops will stimulate molecular breeding for abiotic and biotic stress tolerance/resistance, yield, quality traits, with practical ramifications extending to improvement of biological processes key to productivity, economic yield and ecologically-safe production practices. Overall, economic and societal impacts of whole genome sequencing of priority crops will be compelling on both national and international scales. High throughput genomics is a promising approach in holistic manner for DNA profiling, high throughput genotyping, genome wide association mapping and gene/allele mining for rapid identification and determining the functions of genes associated with key traits such as biotic and abiotic stresses, agronomic, yield and quality traits which has potential application in crop plant improvement programs through marker-assisted selection and genetic engineering. Further, it also offers scope for metabolite profiling to identify metabolic pathways for desired traits. Realizing the immense potential high throughput genomics, concerted efforts are essential for improvement of crop plants at national level.